A Service of the Hamilton Regional Laboratory
Laboratory Test Information
Committed to Quality
The HRLMP is committed to providing high quality laboratory results for our clients.
As one of the largest integrated laboratory medicine programs in Canada we strive to produce the right results the first time on every sample we receive.
Test Name:
TPMT & NUDT15 Molecular Genetic Testing
Alternate Name(s): Thiopurine S-Methyltransferase, Nudix Hydrolase 15, genotyping, mutation, drug dosage, pharmacogenetics
Requisition Form: Download requisition form for: R_R_FINAL_MolecularDiagnostics_June2026.pdf
Specimen Requirement: 4 mL Whole blood collected in EDTA
Storage/ Transport::
 Transport at room temperature. Samples can be stored in the fridge (4'C) for up to one week before shipping.
Turnaround Time: 2 weeks
Additional Information: Genomic DNA is extracted from the submitted specimen and assessed for the presence of
o Thiopurine S-Methyltransferase (TPMT) gene mutations using allele specific polymerase chain reaction (PCR) for the three common variants (c.238G>C, c.460G>A, c.719A>G).
o Nudix Hydrolase-15 (NUDT15) common mutation, c.415C>T, using PCR and direct nucleotide sequencing by Sanger.

For any inquiries, please contact geneticsmailbox@hhsc.ca
Test was Last Updated: 7/2/2026
Testing Laboratory: Clinical Genetics
Testing Site: JHCC