A Service of the Hamilton Regional Laboratory
Laboratory Test Information
Committed to Quality
The HRLMP is committed to providing high quality laboratory results for our clients.
As one of the largest integrated laboratory medicine programs in Canada we strive to produce the right results the first time on every sample we receive.
Test Name:
TPMT Molecular Genetic Testing
Alternate Name(s): Thiopurine S-Methyltransferase, genotyping, mutation, drug dosage, pharmacogenetics, PCR
Requisition Form: Download requisition form for: R_FINAL_MolecularDiagnostics_Jan2025.pdf
Specimen Requirement: 4 mL Whole blood collected in EDTA
Storage/ Transport::
 Transport at room temperature. Samples can be stored in the fridge (4'C) for up to one week before shipping.
Turnaround Time: 2 weeks
Additional Information: Genomic DNA is extracted from the submitted specimen and assessed for the presence of Thiopurine S-Methyltransferase (TPMT) gene mutations using allele specific polymerase chain reaction (PCR) for the three common variants (c.238G>C, c.460G>A, c.719A>G).

For any inquiries, please contact geneticsmailbox@hhsc.ca
Test was Last Updated: 1/17/2025
Testing Laboratory: Clinical Genetics
Testing Site: JHCC